Preheat oven to 400°F.
Line a baking sheet with parchment paper.
On the parchment paper season the ground chicken with ½ t each of Italian seasoning, salt, pepper, garlic powder and onion powder. Mix together with your hands or a spoon.
Mix in ¼ C chopped spinach.
Spread the chicken mixture out thinly on parchment in an oval shape.
Blend the cottage cheese with ¼ t each of Italian seasoning, salt, pepper, garlic powder, and onion powder until smooth.
Stir in chopped spinach with the cottage cheese.
Spread the cottage cheese filling over half of the chicken (leave edges clear).
Add chopped pepperoni over the filling.
Using the parchment paper, fold the calzone over and seal edges.
Top with grated parmesan.
Bake 20 minutes, then carefully pour off any excess liquid before serving. Slice and dip in marinara sauce.